Services
Biological activity and immunogenicity is affected by conformation and the aggregated state. Within most biomolecular species there is inherent instability with many potential degradation pathways which can occur at the processing or storage stages. Our services are based on providing solid state characterisation to support biopharmaceutical formulation development and to optimise processes for delivery of a stable system.
Typical services include:
- Lyophilisation formulation development
- Solid state analysis for lyophilised and polymeric based products
- Solid state analysis for optimisation of colloidal, nanoparticulate and microparticulate products
- Aggregation studies
- Formulation instability determination
- Formulated product–tertiary and solid state structural determination
- Surface analysis and optimisation of delivery systems